ApoB SURFs a Ride from the ER to the Golgi.
Where this comes from
- Record sourced from PubMed, PMID 33535097.
- Also identified by DOI 10.1016/j.cmet.2021.01.007.
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Abstract
Chylomicrons and very-low-density lipoproteins (VLDLs) are large, complex cargos that may require specific chaperones for efficient transport from the ER to Golgi. In this issue of Cell Metabolism, Wang et al. (2020) identify SURF4, in coordination with SAR1B, as an essential player in COPII transport of VLDLs from ER to Golgi, suggesting that SURF4 may be a target for approaches aimed at reducing secretion of triglyceride-rich, atherogenic lipoproteins from the liver.
Medical subject headings
- Apolipoproteins B
- Monomeric GTP-Binding Proteins