Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33547281.
- Also identified by DOI 10.1038/s41467-021-21006-9 and PMC identifier 7864994.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Coronaviruses of bats and pangolins have been implicated in the origin and evolution of the pandemic SARS-CoV-2. We show that spikes from Guangdong Pangolin-CoVs, closely related to SARS-CoV-2, bind strongly to human and pangolin ACE2 receptors. We also report the cryo-EM structure of a Pangolin-CoV spike protein and show it adopts a fully-closed conformation and that, aside from the Receptor-Binding Domain, it resembles the spike of a bat coronavirus RaTG13 more than that of SARS-CoV-2.
Medical subject headings
- COVID-19
- Evolution, Molecular
- SARS-CoV-2
- Spike Glycoprotein, Coronavirus