Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology.
meta_analysis · Level I
Where this comes from
- Record sourced from PubMed, PMID 33547301.
- Also identified by DOI 10.1038/s41467-020-20870-1 and PMC identifier 7865025.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Serum liver enzyme concentrations are the most frequently-used laboratory markers of liver disease, a major cause of mortality. We conduct a meta-analysis of genome-wide association studies of liver enzymes from UK BioBank and BioBank Japan. We identified 160 previously-unreported independent alanine aminotransferase, 190 aspartate aminotransferase, and 199 alkaline phosphatase genome-wide significant associations, with some affecting multiple different enzymes. Associated variants implicate genes that demonstrate diverse liver cell type expression and promote a range of metabolic and liver diseases. These findings provide insight into the pathophysiology of liver and other metabolic diseases that are associated with serum liver enzyme concentrations.
Medical subject headings
- Alanine Transaminase
- Alkaline Phosphatase
- Aspartate Aminotransferases
- Genome, Human
- Liver
- Liver Diseases