Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33558724.
- Also identified by DOI 10.1038/s41591-021-01270-4.
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Abstract
We engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion + N501Y + D614G from UK; and E484K + N501Y + D614G from SA. Neutralization geometric mean titers (GMTs) of 20 BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses.
Medical subject headings
- COVID-19 Vaccines
- Mutation
- Neutralization Tests
- SARS-CoV-2
- Spike Glycoprotein, Coronavirus