Comment on "Structural evidence for a dynamic metallocofactor during N<sub>2</sub> reduction by Mo-nitrogenase".

Peters, John W; Einsle, Oliver; Dean, Dennis R; DeBeer, Serena; Hoffman, Brian M; Holland, Patrick L; Seefeldt, Lance C · Science · 2021

editorial · Level V

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Abstract

Kang <i>et al</i> (Reports, 19 June 2020, p. 1381) report a structure of the nitrogenase MoFe protein that is interpreted to indicate binding of N<sub>2</sub> or an N<sub>2</sub>-derived species to the active-site FeMo cofactor. Independent refinement of the structure and consideration of biochemical evidence do not support this claim.

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