Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33577765.
- Also identified by DOI 10.1016/j.cell.2021.01.035 and PMC identifier 7834972.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is continuing to disrupt personal lives, global healthcare systems, and economies. Hence, there is an urgent need for a vaccine that prevents viral infection, transmission, and disease. Here, we present a two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein. Immunization studies show that this vaccine induces potent neutralizing antibody responses in mice, rabbits, and cynomolgus macaques. The vaccine-induced immunity protects macaques against a high-dose challenge, resulting in strongly reduced viral infection and replication in the upper and lower airways. These nanoparticles are a promising vaccine candidate to curtail the SARS-CoV-2 pandemic.
Medical subject headings
- COVID-19 Vaccines
- Macaca fascicularis
- Spike Glycoprotein, Coronavirus