The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33579792.
- Also identified by DOI 10.1073/pnas.2022586118 and PMC identifier 7936381.
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Abstract
The majority of currently circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses have mutant spike glycoproteins that contain the D614G substitution. Several studies have suggested that spikes with this substitution are associated with higher virus infectivity. We use cryo-electron microscopy to compare G614 and D614 spikes and show that the G614 mutant spike adopts a range of more open conformations that may facilitate binding to the SARS-CoV-2 receptor, ACE2, and the subsequent structural rearrangements required for viral membrane fusion.
Medical subject headings
- COVID-19
- SARS-CoV-2
- Spike Glycoprotein, Coronavirus