DNA methylation status correlates with adult β-cell regeneration capacity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33580013.
- Also identified by DOI 10.1038/s41536-021-00119-1 and PMC identifier 7881134.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findings emphasise DNA methylation is a barrier in β-cell regeneration in adulthood, a well described pathophysiological phenomenon of major significance in explaining β-cell deficiency in diabetes in the adult pancreas.