Health Outcomes of Infants with Vitamin B₁₂ Deficiency Identified by Newborn Screening and Early Treated.

Abstract

To evaluate the clinical outcomes at age 1.5 ± 0.5 years of infants with vitamin B₁₂ deficiency identified by newborn screening (NBS). Prospective multicenter observational study on health outcomes of 31 infants with vitamin B₁₂ deficiency identified by NBS. Neurodevelopment was assessed by the Denver Developmental Screening Test. In 285 862 newborns screened between 2016 and 2019, the estimated birth prevalence of vitamin B₁₂ deficiency was 26 in 100 000 newborns, with high seasonal variations (lowest in summer: 8 in 100 000). Infants participating in the outcome study (N = 31) were supplemented with vitamin B₁₂ for a median (range) of 5.9 (1.1-16.2) months. All achieved age-appropriate test results in Denver Developmental Screening Test at age 15 (11-23) months and did not present with symptoms characteristic for vitamin B₁₂ deficiency. Most (81%, n = 25) mothers of affected newborns had a hitherto undiagnosed (functional) vitamin B₁₂ deficiency, and, subsequently, received specific therapy. Neonatal vitamin B₁₂ deficiency can be screened by NBS, preventing the manifestation of irreversible neurologic symptoms and the recurrence of vitamin B₁₂ deficiency in future pregnancies through adequate treatment of affected newborns and their mothers. The high frequency of mothers with migrant background having a newborn with vitamin B₁₂ deficiency highlights the need for improved prenatal care.