The effect of denosumab administration on bone metabolism for treatment of spinal metastasis.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 33603317.
- Also identified by DOI 10.1016/j.jor.2021.01.009 and PMC identifier 7868681.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We investigated changes in bone metabolism markers over time for evaluating the effect of denosumab following administration to patients with spinal metastasis. Subjects of this study were 28 patients treated at the Department of Orthopedic Surgery at Aichi Medical University. At 6 months after denosumab intervention, measured TRAP-5b values were significantly lower compared to pre-intervention values in both the osteosclerotic lesion and osteolytic lesion groups. This change in bone metabolism marker values over time is one of the methods for evaluating the effect of treatment on bone tissue in cases of spinal metastasis.