Susceptibility and Attenuated Transmissibility of SARS-CoV-2 in Domestic Cats.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33605423.
- Also identified by DOI 10.1093/infdis/jiab104 and PMC identifier 7928776.
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Abstract
Domestic cats, an important companion animal, can be infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This has aroused concern regarding the ability of domestic cats to spread the virus that causes coronavirus disease 2019. We systematically demonstrated the pathogenesis and transmissibility of SARS-CoV-2 in cats. Serial passaging of the virus between cats dramatically attenuated the viral transmissibility, likely owing to variations of the amino acids in the receptor-binding domain sites of angiotensin-converting enzyme 2 between humans and cats. These findings provide insight into the transmissibility of SARS-CoV-2 in cats and information for protecting the health of humans and cats.
Medical subject headings
- COVID-19
- SARS-CoV-2