Effect of Body Weight and Age on the Pharmacokinetics of Dihydroartemisinin: Food and Drug Administration Basis for Dose Determination of Artesunate for Injection in Pediatric Patients With Severe Malaria.
expert_opinion · Level V
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- Record sourced from PubMed, PMID 33605994.
- Also identified by DOI 10.1093/cid/ciab149.
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Abstract
For treatment of severe malaria, the World Health Organization recommends 3 mg/kg intravenous artesunate in pediatric patients weighing less than 20 kg. Here we describe the Food and Drug Administration's rationale for selecting 2.4 mg/kg in pediatric patients weighing less than 20 kg based on literature review and independent analyses.
Medical subject headings
- Antimalarials
- Malaria
- Malaria, Falciparum