The Complement Pathway Is Activated in People With Human Immunodeficiency Virus and Is Associated With Non-AIDS Comorbidities.

Vujkovic-Cvijin, Ivan; Sortino, Ornella; Verheij, Eveline; Wit, Ferdinand W; Kootstra, Neeltje A; Sellers, Brian; Schim van der Loeff, Maarten; Belkaid, Yasmine et al. · J Infect Dis · 2021

case_control · Level III

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Abstract

Unbiased plasma proteomics in a matched case-control study of treated people with human immunodeficiency virus (PWH) revealed the complement cascade as being among the top pathways enriched in PWH. Specific complement components, namely C5, associated significantly with non-AIDS comorbidity prevalence, and did so more strongly than previously established predictive biomarkers.

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