"Iron"ing out hemophagocytosis through PIEZO1.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33606984.
- Also identified by DOI 10.1016/j.cell.2021.01.038 and PMC identifier 9979154.
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Abstract
In this issue of Cell, Ma et al. reveal a mechanistic role for PIEZO1 in iron homeostasis through molecular genetic mouse studies. They also demonstrate implications for human iron overload and deficiency syndromes, susceptibility to malarial infection, and red blood cell turnover in persons of African ancestries.
Medical subject headings
- Iron
- Malaria