Regulation of Hepatic Metabolism and Cell Growth by the ATF/CREB Family of Transcription Factors.
review · Level V
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- Record sourced from PubMed, PMID 33608424.
- Also identified by DOI 10.2337/dbi20-0006 and PMC identifier 7897342.
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Abstract
The liver is a major metabolic organ that regulates the whole-body metabolic homeostasis and controls hepatocyte proliferation and growth. The ATF/CREB family of transcription factors integrates nutritional and growth signals to the regulation of metabolism and cell growth in the liver, and deregulated ATF/CREB family signaling is implicated in the progression of type 2 diabetes, nonalcoholic fatty liver disease, and cancer. This article focuses on the roles of the ATF/CREB family in the regulation of glucose and lipid metabolism and cell growth and its importance in liver physiology. We also highlight how the disrupted ATF/CREB network contributes to human diseases and discuss the perspectives of therapeutically targeting ATF/CREB members in the clinic.
Medical subject headings
- Activating Transcription Factors
- Cyclic AMP Response Element-Binding Protein
- Liver