Polygenic hazard score is associated with prostate cancer in multi-ethnic populations.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 33623038.
- Also identified by DOI 10.1038/s41467-021-21287-0 and PMC identifier 7902617.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS<sub>1</sub>) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS<sub>2</sub> (PHS<sub>1</sub>, adapted for OncoArray) in a multi-ethnic dataset of 80,491 men (49,916 cases, 30,575 controls). PHS<sub>2</sub> is associated with age at diagnosis of any and aggressive (Gleason score ≥ 7, stage T3-T4, PSA ≥ 10 ng/mL, or nodal/distant metastasis) cancer and prostate-cancer-specific death. Associations with cancer are significant within European (n = 71,856), Asian (n = 2,382), and African (n = 6,253) genetic ancestries (p < 10<sup>-180</sup>). Comparing the 80<sup>th</sup>/20<sup>th</sup> PHS<sub>2</sub> percentiles, hazard ratios for prostate cancer, aggressive cancer, and prostate-cancer-specific death are 5.32, 5.88, and 5.68, respectively. Within European, Asian, and African ancestries, hazard ratios for prostate cancer are: 5.54, 4.49, and 2.54, respectively. PHS<sub>2</sub> risk-stratifies men for any, aggressive, and fatal prostate cancer in a multi-ethnic dataset.
Medical subject headings
- Ethnicity
- Multifactorial Inheritance
- Prostatic Neoplasms