Wireless Optogenetic Modulation of Cortical Neurons Enabled by Radioluminescent Nanoparticles.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33625219.
- Also identified by DOI 10.1021/acsnano.0c10436.
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Abstract
While offering high-precision control of neural circuits, optogenetics is hampered by the necessity to implant fiber-optic waveguides in order to deliver photons to genetically engineered light-gated neurons in the brain. Unlike laser light, X-rays freely pass biological barriers. Here we show that radioluminescent Gd<sub>2</sub>(WO<sub>4</sub>)<sub>3</sub>:Eu nanoparticles, which absorb external X-rays energy and then downconvert it into optical photons with wavelengths of ∼610 nm, can be used for the transcranial stimulation of cortical neurons expressing red-shifted, ∼590-630 nm, channelrhodopsin ReaChR, thereby promoting optogenetic neural control to the practical implementation of minimally invasive wireless deep brain stimulation.
Medical subject headings
- Nanoparticles
- Optogenetics