Bronchiectasis severity correlates with outcome in patients with primary antibody deficiency.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 33632768.
- Also identified by DOI 10.1136/thoraxjnl-2020-215585.
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Abstract
Bronchiectasis is a well-recognised complication of primary antibody deficiency (PAD) syndromes. Previous data suggest that mortality in common variable immune deficiency (CVID) is not associated with isolated bronchiectasis. A retrospective analysis of patients with CVID and specific antibody deficiency in two tertiary referral centres with lung disease was conducted. Severity of bronchiectasis at presentation was associated with mortality. Lower FEV<sub>1</sub>, colonisation with <i>Pseudomonas aeruginosa</i> and a diagnosis of COPD were also associated with mortality. Bronchiectasis is an important driver of mortality in patients with PAD syndromes.
Medical subject headings
- Bronchiectasis
- Common Variable Immunodeficiency
- Lung Diseases
- Primary Immunodeficiency Diseases