Repeatability and sensitivity to change of non-invasive end points in PAH: the RESPIRE study.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 33632769.
- Also identified by DOI 10.1136/thoraxjnl-2020-216078 and PMC identifier 8461450.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
End points that are repeatable and sensitive to change are important in pulmonary arterial hypertension (PAH) for clinical practice and trials of new therapies. In 42 patients with PAH, test-retest repeatability was assessed using the intraclass correlation coefficient and treatment effect size using Cohen's d statistic. Intraclass correlation coefficients demonstrated excellent repeatability for MRI, 6 min walk test and log to base 10 N-terminal pro-brain natriuretic peptide (log<sub>10</sub>NT-proBNP). The treatment effect size for MRI-derived right ventricular ejection fraction was large (Cohen's d 0.81), whereas the effect size for the 6 min walk test (Cohen's d 0.22) and log<sub>10</sub>NT-proBNP (Cohen's d 0.20) were fair. This study supports further evaluation of MRI as a non-invasive end point for clinical assessment and PAH therapy trials.Trial registration number NCT03841344.
Medical subject headings
- Hypertension, Pulmonary
- Pulmonary Arterial Hypertension