Bone resorption goes green.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 33636131.
- Also identified by DOI 10.1016/j.cell.2021.02.023 and PMC identifier 11658024.
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Abstract
In this issue of Cell, McDonald et al. show that giant multinucleated, bone-resorbing osteoclasts dissolve into smaller cells, termed "osteopmorhs," which re-form into osteoclasts at distal bone sites (McDonald et al., 2021). These findings overturn the long-standing premise that osteoclasts differentiate solely from hematopoietic precursors and undergo apoptosis after completing resorption.
Medical subject headings
- Bone Resorption