Recurrent membranous nephropathy after transplantation: donor antigen and HLA converge in defining risk.
Where this comes from
- Record sourced from PubMed, PMID 33637201.
- Also identified by DOI 10.1016/j.kint.2020.10.044.
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Abstract
Membranous nephropathy, like many forms of glomerulonephritis, is an HLA-associated autoimmune disease that can recur in the transplanted kidney. In this issue of Kidney International, Berchtold and colleagues publish an intriguing and important paper on risk factors for recurrent post-transplant membranous nephropathy due to autoimmunity to PLA2R1. They found that the genetics of both the autoantigen and donor HLA are important determinants of the risk of recurrent disease in the graft.
Medical subject headings
- Glomerulonephritis
- Glomerulonephritis, Membranous
- Kidney Transplantation