In hyponatremia, rapid intermittent bolus vs. slow continuous infusion of hypertonic saline did not differ for overcorrection of serum sodium.

Donato, Anthony A; Lloyd, Benjamin J · Ann Intern Med · 2021

rct · Level II

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Abstract

Baek SH, Jo YH, Ahn S, et al. <b>Risk of overcorrection in rapid intermittent bolus vs slow continuous infusion therapies of hypertonic saline for patients with symptomatic hyponatremia: the SALSA randomized clinical trial.</b> JAMA Intern Med. 2021;181:81-92. 33104189.

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