DNA stability: a central design consideration for DNA data storage systems.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 33649304.
- Also identified by DOI 10.1038/s41467-021-21587-5 and PMC identifier 7921107.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Data storage in DNA is a rapidly evolving technology that could be a transformative solution for the rising energy, materials, and space needs of modern information storage. Given that the information medium is DNA itself, its stability under different storage and processing conditions will fundamentally impact and constrain design considerations and data system capabilities. Here we analyze the storage conditions, molecular mechanisms, and stabilization strategies influencing DNA stability and pose specific design configurations and scenarios for future systems that best leverage the considerable advantages of DNA storage.
Medical subject headings
- DNA
- Data Systems
- Information Storage and Retrieval