SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33654292.
- Also identified by DOI 10.1038/s41591-021-01285-x.
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Abstract
SARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that pseudovirus expressing 501Y.V2 spike protein completely escapes three classes of therapeutically relevant antibodies. This pseudovirus also exhibits substantial to complete escape from neutralization, but not binding, by convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and foreshadows reduced efficacy of spike-based vaccines.
Medical subject headings
- COVID-19
- Immune Evasion
- Neutralization Tests
- SARS-CoV-2