Group testing as a strategy for COVID-19 epidemiological monitoring and community surveillance.
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Where this comes from
- Record sourced from PubMed, PMID 33661887.
- Also identified by DOI 10.1371/journal.pcbi.1008726 and PMC identifier 7932094.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
We propose an analysis and applications of sample pooling to the epidemiologic monitoring of COVID-19. We first introduce a model of the RT-qPCR process used to test for the presence of virus in a sample and construct a statistical model for the viral load in a typical infected individual inspired by large-scale clinical datasets. We present an application of group testing for the prevention of epidemic outbreak in closed connected communities. We then propose a method for the measure of the prevalence in a population taking into account the increased number of false negatives associated with the group testing method.
Medical subject headings
- COVID-19
- COVID-19 Testing
- Epidemiological Monitoring
- Group Processes
- Population Surveillance
- SARS-CoV-2