Selection of different endothelialization modes and different seed cells for tissue-engineered vascular graft.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 33665496.
- Also identified by DOI 10.1016/j.bioactmat.2020.12.021 and PMC identifier 7887299.
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Abstract
Tissue-engineered vascular grafts (TEVGs) have enormous potential for vascular replacement therapy. However, thrombosis and intimal hyperplasia are important problems associated with TEVGs especially small diameter TEVGs (<6 mm) after transplantation. Endothelialization of TEVGs is a key point to prevent thrombosis. Here, we discuss different types of endothelialization and different seed cells of tissue-engineered vascular grafts. Meanwhile, endothelial heterogeneity is also discussed. Based on it, we provide a new perspective for selecting suitable types of endothelialization and suitable seed cells to improve the long-term patency rate of tissue-engineered vascular grafts with different diameters and lengths.