Myeloproliferative Neoplasms: The Long Wait for JAK2-Mutant Clone Expansion.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 33667352.
- Also identified by DOI 10.1016/j.stem.2021.02.018.
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Abstract
Myeloproliferative neoplasms (MPNs) are hematological malignancies caused by somatic mutations originating from a single hematopoietic stem cell (HSC). In this issue of Cell Stem Cell,Van Egeren et al. (2021) used whole-genome sequencing of hematopoietic colonies to reconstruct the clonal history and time of acquisition of the disease-initiating gene mutation.
Medical subject headings
- Hematologic Neoplasms
- Myeloproliferative Disorders