Stabilizing Formative Pluripotent States with Germ Cell Competency.
editorial · Level V
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- Record sourced from PubMed, PMID 33667353.
- Also identified by DOI 10.1016/j.stem.2021.02.021.
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Abstract
Previous work demonstrating the existence of intermediate pluripotency states in post-implantation embryos had ignited a debate on whether "formative" pluripotency can be stabilized in pluripotent stem cell (PSC) lines. In this issue of Cell Stem Cell, two papers show that polarized epithelial and germ cell-competent formative PSCs can be maintained in modified activin-dependent conditions.
Medical subject headings
- Pluripotent Stem Cells