Lysosomal Regulation of Metabolism in Quiescent Hematopoietic Stem Cells: More than Just Autophagy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33667358.
- Also identified by DOI 10.1016/j.stem.2021.02.017 and PMC identifier 8147711.
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Abstract
The depth of quiescence in hematopoietic stem cells (HSCs) dictates their potency and is sensitive to metabolic perturbations. Recent evidence suggests that lysosomal functions distinct from autophagic processes are pivotal in regulating quiescence versus activation by potential control of the access to a nutrient reservoir required for HSC activation.
Medical subject headings
- Hematopoietic Stem Cells
- Lysosomes