Mitochondria as Signaling Organelles Control Mammalian Stem Cell Fate.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 33667360.
- Also identified by DOI 10.1016/j.stem.2021.02.011 and PMC identifier 7944920.
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Abstract
Recent evidence supports the notion that mitochondrial metabolism is necessary for the determination of stem cell fate. Historically, mitochondrial metabolism is linked to the production of ATP and tricarboxylic acid (TCA) cycle metabolites to support stem cell survival and growth, respectively. However, it is now clear that beyond these canonical roles, mitochondria as signaling organelles dictate stem cell fate and function. In this review, we focus on key conceptual ideas on how mitochondria control mammalian stem cell fate and function through reactive oxygen species (ROS) generation, TCA cycle metabolite production, NAD<sup>+</sup>/NADH ratio regulation, pyruvate metabolism, and mitochondrial dynamics.
Medical subject headings
- Mitochondria
- Signal Transduction