How to make a better T cell: in vivo CRISPR screens have some answers.
editorial · Level V
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- Record sourced from PubMed, PMID 33667366.
- Also identified by DOI 10.1016/j.cell.2021.02.003.
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Abstract
Understanding what regulates CD8<sup>+</sup> T cell responses is key to effectively harnessing these cells in human disease. In this issue of Cell, Huang et al. and Chen et al. use in vivo CRISPR screens to discover novel regulators of CD8<sup>+</sup> T cell immunity to engineer a more efficacious response against cancer and infections.
Medical subject headings
- Clustered Regularly Interspaced Short Palindromic Repeats
- Neoplasms