Plasmonic-Fluorescent Janus Ag/Ag<sub>2</sub>S Nanoparticles for <i>In Situ</i> H<sub>2</sub>O<sub>2</sub>-Activated NIR-II Fluorescence Imaging.
basic_science · Level V
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- Record sourced from PubMed, PMID 33683889.
- Also identified by DOI 10.1021/acs.nanolett.1c00197.
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Abstract
Silver sulfide (Ag<sub>2</sub>S) has gained widespread attention in second near-infrared (950-1700 nm, NIR-II) window imaging because of its high fluorescence quantum yield and low toxicity. However, its "always on" fluorescence shows inapplicability for targeted molecule-activated biomedical applications. Herein, we first developed a novel silver/silver sulfide Janus nanoparticle (Ag/Ag<sub>2</sub>S JNP) for specific activatable fluorescence imaging in the NIR-II window. Inner-particle electron compensation from Ag to Ag<sub>2</sub>S upon laser irradiation endowed JNPs an "off" state of fluorescence, whereas the oxidization of Ag incubated with H<sub>2</sub>O<sub>2</sub>, decreasing the electron-transfer effect and illuminating the NIR-II fluorescence of the Ag<sub>2</sub>S part. In contrast, the absorption of Ag/Ag<sub>2</sub>S JNPs slightly decreased in an H<sub>2</sub>O<sub>2</sub>-dependent manner, showing an activated photoacoustic imaging mechanism. The Ag/Ag<sub>2</sub>S JNPs were used for noninvasive location and diagnosis of diseases <i>in vivo</i>, such as for liver injury and cancer, with high sensitivity and accuracy.