Disruption of neonatal Purkinje cell function underlies injury-related learning deficits.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33688045.
- Also identified by DOI 10.1073/pnas.2017876118 and PMC identifier 7980280.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
It is hypothesized that perinatal cerebellar injury leads to long-term functional deficits due to circuit dysmaturation. Using a novel integration of GCaMP6f fiber photometry with automated measurement of cerebellar behavior using the ErasmusLadder, we causally link cerebellar injury to altered Purkinje cell responses during maladaptive behavior. Chemogenetic inhibition of neonatal Purkinje cells is sufficient to phenocopy the effects of perinatal cerebellar injury. Our results uncover a direct link between perinatal cerebellar injury and activity-dependent maturation of cerebellar cortex.
Medical subject headings
- Cerebellar Diseases
- Learning Disabilities
- Purkinje Cells