Frailty and Risk of Dementia in Mild Cognitive Impairment Subtypes.
retrospective_cohort · Level III
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- Record sourced from PubMed, PMID 33704823.
- Also identified by DOI 10.1002/ana.26064.
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Abstract
Risk factors for developing dementia from mild cognitive impairment (MCI) probably differ between MCI subtypes. We investigated how frailty relates to dementia risk in amnestic MCI (a-MCI; n = 2,799) and non-amnestic MCI (na-MCI; n = 629) in the National Alzheimer's Coordinating Center database. Although higher frailty increased dementia risk for people with either a-MCI or na-MCI, the larger risk was in na-MCI (interaction hazard ratio = 1.35 [95% confidence interval = 1.15-1.59], p < 0.001). Even after the onset of clinically significant cognitive impairment, poor general health, quantified by a high degree of frailty, is a significant risk for dementia. ANN NEUROL 2021;89:1221-1225.
Medical subject headings
- Cognitive Dysfunction
- Dementia
- Frailty