Dual Ni/photoredox-catalyzed asymmetric cross-coupling to access chiral benzylic boronic esters.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33712612.
- Also identified by DOI 10.1038/s41467-021-21947-1 and PMC identifier 7954797.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The flourishing Ni/photoredox-catalyzed asymmetric couplings typically rely on redox-neutral reactions. In this work, we report a reductive cross-coupling of aryl iodides and α-chloroboranes under a dual catalytic regime to further enrich the metallaphotoredox chemistry. This approach proceeds under mild conditions (visible light, ambient temperature, no strong base) to access the versatile benzylic boronic esters with good functional group tolerance and excellent enantioselectivities.