A Tapered-pulsed Fidaxomicin Regimen Following Treatment in Patients With Multiple Clostridioides difficile Infection Recurrences.

Skinner, Andrew M; Tan, Xing; Sirbu, Benjamin D; Danziger, Larry H; Gerding, Dale N; Johnson, Stuart · Clin Infect Dis · 2021

case_series · Level IV

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Abstract

We treated 46 patients with multiple recurrent Clostridioides difficile infections (mrCDI) using a tapered-pulsed (T-P) fidaxomicin regimen, the majority of whom failed prior T-P vancomycin treatment. Sustained clinical response rates at 30 and 90 days were 74% (34/46) and 61% (28/46). T-P fidaxomicin shows promise for management of mrCDI.

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