Integrative transcription start site identification with iTiSS.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33720332.
- Also identified by DOI 10.1093/bioinformatics/btab170.
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Abstract
Many experimental approaches have been developed to identify transcription start sites (TSS) from genomic scale data. However, experiment specific biases lead to large numbers of false-positive calls. Here, we present our integrative approach iTiSS, which is an accurate and generic TSS caller for any TSS profiling experiment in eukaryotes, and substantially reduces the number of false positives by a joint analysis of several complementary datasets. iTiSS is platform independent and implemented in Java (v1.8) and is freely available at https://www.erhard-lab.de/software and https://github.com/erhard-lab/iTiSS. Supplementary data are available at Bioinformatics online.
Medical subject headings
- Software
- Genomics