Locus coeruleus spiking differently correlates with S1 cortex activity and pupil diameter in a tactile detection task.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33721552.
- Also identified by DOI 10.7554/eLife.64327 and PMC identifier 7963470.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
We examined the relationships between activity in the locus coeruleus (LC), activity in the primary somatosensory cortex (S1), and pupil diameter in mice performing a tactile detection task. While LC spiking consistently preceded S1 membrane potential depolarization and pupil dilation, the correlation between S1 and pupil was more heterogeneous. Furthermore, the relationships between LC, S1, and pupil varied on timescales of sub-seconds to seconds within trials. Our data suggest that pupil diameter can be dissociated from LC spiking and cannot be used as a stationary index of LC activity.
Medical subject headings
- Locus Coeruleus
- Pupil
- Somatosensory Cortex