The role of noradrenaline in cognition and cognitive disorders.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 33725122.
- Also identified by DOI 10.1093/brain/awab111 and PMC identifier 8418349.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Many aspects of cognition and behaviour are regulated by noradrenergic projections to the forebrain originating from the locus coeruleus, acting through alpha and beta adrenoreceptors. Loss of these projections is common in neurodegenerative diseases and contributes to their cognitive and behavioural deficits. We review the evidence for a noradrenergic modulation of cognition in its contribution to Alzheimer's disease, Parkinson's disease and other cognitive disorders. We discuss the advances in human imaging and computational methods that quantify the locus coeruleus and its function in humans, and highlight the potential for new noradrenergic treatment strategies.
Medical subject headings
- Cognition
- Cognition Disorders
- Locus Coeruleus
- Norepinephrine