Esophageal Epidermoid Metaplasia: Clinical Characteristics and Risk of Esophageal Squamous Neoplasia.

Kamboj, Amrit K; Gibbens, Ying Y; Hagen, Catherine E; Wang, Kenneth K; Iyer, Prasad G; Katzka, David A · Am J Gastroenterol · 2021

case_series · Level IV

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Abstract

Esophageal epidermoid metaplasia (EEM) is a rare disease. Patients with EEM diagnosed between 2014 and 2020 were reviewed. Forty EEM cases were identified. EEM occurred in 9 (23%) patients before, concordant, or after esophageal squamous cell carcinoma (ESCC). EEM was associated with previous esophageal lichen planus in 5 patients, Barrett's esophagus 7, and esophageal adenocarcinoma 1. EEM was focal in 28 (70%) or diffuse in 12 (30%) and not detected in 45% on recent previous endoscopy. EEM is a premalignant underrecognized condition associated with multiple conditions. Close follow-up or endoscopic treatment may be warranted because of its ESCC association.

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