A review and roadmap of the skin, lung and gut microbiota in systemic sclerosis.
review · Level V
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- Record sourced from PubMed, PMID 33734316.
- Also identified by DOI 10.1093/rheumatology/keab262 and PMC identifier 8643452.
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Abstract
As our understanding of the genetic underpinnings of SSc increases, questions regarding the environmental trigger(s) that induce and propagate SSc in the genetically predisposed individual emerge. The interplay between the environment, the immune system, and the microbial species that inhabit the patient's skin and gastrointestinal tract is a pathobiological frontier that is largely unexplored in SSc. The purpose of this review is to provide an overview of the methodologies, experimental study results and future roadmap for elucidating the relationship between the SSc host and his/her microbiome.
Medical subject headings
- Gastrointestinal Microbiome
- Gastrointestinal Tract
- Lung
- Scleroderma, Systemic
- Skin