A Noninvasive Method for Quantifying Cerebral Metabolic Rate of Oxygen by Hybrid PET/MRI: Validation in a Porcine Model.

Narciso, Lucas; Ssali, Tracy; Liu, Linshan; Biernaski, Heather; Butler, John; Morrison, Laura; Hadway, Jennifer; Corsaut, Jeffrey et al. · J Nucl Med · 2021

basic_science · Level V

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Abstract

The gold standard for imaging the cerebral metabolic rate of oxygen (CMRO<sub>2</sub>) is positron emission tomography (PET); however, it is an invasive and complex procedure that also requires correction for recirculating <sup>15</sup>O-H<sub>2</sub>O and the blood-borne activity. We propose a noninvasive reference-based hybrid PET/magnetic resonance imaging (MRI) method that uses functional MRI techniques to calibrate <sup>15</sup>O-O<sub>2</sub>-PET data. Here, PET/MR imaging of oxidative metabolism (PMROx) was validated in an animal model by comparison to PET-alone measurements. Additionally, we investigated if the MRI-perfusion technique arterial spin labelling (ASL) could be used to further simplify PMROx by replacing <sup>15</sup>O-H<sub>2</sub>O-PET, and if the PMROx was sensitive to anesthetics-induced changes in metabolism. <b>Methods:</b> <sup>15</sup>O-H<sub>2</sub>O and <sup>15</sup>O-O<sub>2</sub> PET data were acquired in a hybrid PET/MR scanner (3 T Siemens Biograph mMR), together with simultaneous functional MRI (OxFlow and ASL), from juvenile pigs (<i>n</i> = 9). Animals were anesthetized with 3% isoflurane and 6 mL/kg/h propofol for the validation experiments and arterial sampling was performed for PET-alone measurements. PMROx estimates were obtained using whole-brain (WB) CMRO<sub>2</sub> from OxFlow and local cerebral blood flow (CBF) from either noninvasive <sup>15</sup>O-H<sub>2</sub>O-PET or ASL (PMROxASL). Changes in metabolism were investigated by increasing the propofol infusion to 20 mL/kg/h. <b>Results:</b> Good agreement and correlation were observed between regional CMRO<sub>2</sub> measurements from PMROx and PET-alone. No significant differences were found between OxFlow and PET-only measurements of WB oxygen extraction fraction (0.30 ± 0.09 and 0.31 ± 0.09) and CBF (54.1 ± 16.7 and 56.6 ± 21.0 mL/100 g/min), or between PMROx and PET-only CMRO<sub>2</sub> estimates (1.89 ± 0.16 and 1.81 ± 0.10 mLO<sub>2</sub>/100 g/min). Moreover, PMROx and PMROxASL were sensitive to propofol-induced reduction in CMRO<sub>2</sub> <b>Conclusion:</b> This study provides initial validation of a noninvasive PET/MRI technique that circumvents many of the complexities of PET CMRO<sub>2</sub> imaging. PMROx does not require arterial sampling and has the potential to reduce PET imaging to <sup>15</sup>O-O<sub>2</sub> only; however, future validation involving human participants are required.