Extending the Near-Infrared Emission Range of Indium Phosphide Quantum Dots for Multiplexed <i>In Vivo</i> Imaging.
basic_science · Level V
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- Record sourced from PubMed, PMID 33755481.
- Also identified by DOI 10.1021/acs.nanolett.1c00600 and PMC identifier 8243857.
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Abstract
This report of the reddest emitting indium phosphide quantum dots (InP QDs) to date demonstrates tunable, near-infrared (NIR) photoluminescence (PL) as well as PL multiplexing in the first optical tissue window while avoiding toxic constituents. This synthesis overcomes the InP "growth bottleneck" and extends the emission peak of InP QDs deeper into the first optical tissue window using an inverted QD heterostructure, specifically ZnSe/InP/ZnS core/shell/shell nanoparticles. The QDs exhibit InP shell thickness-dependent tunable emission with peaks ranging from 515-845 nm. The high absorptivity of InP yields effective photoexcitation of the QDs with UV, visible, and NIR wavelengths. These nanoparticles extend the range of tunable direct-bandgap emission from InP-based nanostructures, effectively overcoming a synthetic barrier that has prevented InP-based QDs from reaching their full potential as NIR imaging agents. Multiplexed lymph node imaging in a mouse model demonstrates the potential of the NIR-emitting InP particles for <i>in vivo</i> imaging.
Medical subject headings
- Phosphines
- Quantum Dots