Oncometabolites in Cancer: Current Understanding and Challenges.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 33762356.
- Also identified by DOI 10.1158/0008-5472.CAN-20-3730.
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Abstract
Oncometabolites are pathognomonic hallmarks in human cancers, including glioma, leukemia, neuroendocrine tumors, and renal cancer. Oncometabolites are aberrantly accumulated from disrupted Krebs cycle and affect the catalytic activity of α-ketoglutarate-dependent dioxygenases. Oncometabolites indicate distinct cancer-related patterns ranging from oncogenesis and metabolism to therapeutic resistance. Here we discuss the current understanding of oncometabolites as well as the controversies and challenges associated with oncometabolite-driven cancers. New insights into the relationship between cancer and oncometabolites will elucidate novel therapeutic avenues for improved cancer treatment.
Medical subject headings
- Carcinogenesis
- Citric Acid Cycle
- Metabolome
- Neoplasms