Therapeutic Escape in Gαq-mutant Uveal Melanoma: It's a FAK.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 33766812.
- Also identified by DOI 10.1158/1078-0432.CCR-21-0567 and PMC identifier 8172474.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Through a synthetic lethal screen, ERK activation was found to mediate resistance to FAK inhibition in GNAQ-mutant uveal melanoma. With PLCB-PKC-ERK and Trio-FAK-Yap representing compensatory effectors of mutant Gαq signaling, combined inhibition of both pathways may be a promising therapeutic strategy in metastatic uveal melanoma.<i>See related article by Paradis et al., p. 3190</i>.
Medical subject headings
- GTP-Binding Protein alpha Subunits
- Uveal Neoplasms