Cross-kingdom metabolic manipulation promotes Salmonella replication inside macrophages.
Where this comes from
- Record sourced from PubMed, PMID 33767154.
- Also identified by DOI 10.1038/s41467-021-22198-w and PMC identifier 7994845.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Replication inside macrophages is crucial for systemic dissemination of <i>Salmonella</i> in hosts. In a <i>Nature Communications</i> article, Jiang et al. show that <i>Salmonella</i> stimulates glycolysis and represses serine synthesis in macrophages, leading to accumulation of host glycolytic intermediates that the bacteria use as carbon source and as cues for its replication.
Medical subject headings
- Macrophages
- Salmonella typhimurium