Back from the Brink: EGFR Inhibition in Gastroesophageal Cancer.

Openshaw, Mark R; Pinato, David J; Valeri, Nicola · Clin Cancer Res · 2021

editorial · Level V

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Abstract

Gastroesophageal adenocarcinomas (GEA) remain difficult to treat with limited targeted therapeutics. Negative results from randomized trials of EGFR inhibitors (EGFRi) in patients with molecularly unselected GEA have hampered the development of EGFRi in the gastroesophageal cancer space. A recent study reopens the game.<i>See related article by Corso et al., p. 3126</i>.

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