Watchful waiting for small non-functional pancreatic neuroendocrine tumours: nationwide prospective cohort study (PANDORA).
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 33783475.
- Also identified by DOI 10.1093/bjs/znab088 and PMC identifier 10364894.
- Licence recorded as CC BY-NC.
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Abstract
This prospective nationwide cohort study examined the feasibility of a watchful-waiting protocol for non-functional pancreatic neuroendocrine tumours (NF-pNET) of 2 cm or smaller. In total, 8 of 76 patients (11 per cent) with a NF-pNET no larger than 2 cm showed significant tumour progression (more than 0.5 cm/year) during 17 months of follow-up, of whom two opted for resection. No patient developed metastases. Quality of life was poorer than in the reference population. Watchful waiting seems a safe alternative to upfront surgery in patients with a NF-pNET no larger than 2 cm, although longer follow-up is necessary.
Medical subject headings
- Neoplasm Staging
- Pancreatectomy
- Pancreatic Neoplasms
- Watchful Waiting