Bioenergetics matter to metabolic health-from a fat progenitor view.

Kajimura, Shingo · Cell Stem Cell · 2021

editorial · Level V

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Abstract

The response of adipose progenitors to metabolic states is a crucial, but poorly understood, determinant of metabolic health. The back-to-back papers by Joffin et al. (2021) and Shao et al. (2021) in this issue of Cell Stem Cell reveal how adipose-tissue-resident PDGFRβ<sup>+</sup>precursor cell fate is regulated by mitochondrial bioenergetic state and how such processes go wrong in obesity.

Medical subject headings