A near infrared ratiometric platform based π-extended porphyrin metal-organic framework for O<sub>2</sub> imaging and cancer therapy.
basic_science · Level V
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- Record sourced from PubMed, PMID 33819816.
- Also identified by DOI 10.1016/j.biomaterials.2021.120782.
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Abstract
Photodynamic therapy (PDT) is widely researched in tumor treatment, but its therapeutic effect is affected by oxygen (O<sub>2</sub>) concentration of tumor site. Here, we developed a Pd-coordinated π-conjugated extended porphyrin doped porphyrin metal-organic-framework (named as PTP). PTP can achieve near infrared (NIR) O<sub>2</sub> concentration ratiometric imaging, solving the problems of short detection wavelengths and influence of self-concentrations. With the NIR excitation wavelength and the ability of higher singlet oxygen (<sup>1</sup>O<sub>2</sub>) generation, PTP can induce PDT more effectively. The efficient PDT also mediates cancer immunogenic cell death (ICD), which combines with the immune checkpoint inhibitor αPD-1 to achieve obviously cancer suppression and anti-metastasis effect. This theranostic NIR ratiometric nanoprobe can be used as a pre-evaluation on the outcome of PDT and high-efficient cancer combined treatment system, which will find great potential in tumor diagnosis and treatment.
Medical subject headings
- Metal-Organic Frameworks
- Nanoparticles
- Neoplasms
- Photochemotherapy
- Porphyrins